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BD-1063 dhydrochloride

Chemical Structure : BD-1063 dhydrochloride

CAS No.: 206996-13-6

BD-1063 dhydrochloride (BD1063 dhydrochloride)

Catalog No.: PC-45420Not For Human Use, Lab Use Only.

BD-1063 dhydrochloride (BD1063) is a potent, selective sigma-1 receptor antagonist with binding Ki of 9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BD-1063 dhydrochloride (BD1063) is a potent, selective sigma-1 receptor antagonist with binding Ki of 9 nM.
BD-1063 displays >49-fold selectivity over the sigma-2 receptor.
BD-1063 significantly reverses the neuroprotective effect of DHEA-S against NMDA-induced neurotoxicity in rat hippocampal neurons.

Physicochemical Properties

M.Wt 346.1233
Formula C13H20Cl4N2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

100 mM in H2O

Chemical Name/SMILES

Piperazine, 1-[2-(3,4-dichlorophenyl)ethyl]-4-methyl-, hydrochloride (1:2)

References

1. Matsumoto RR, et al. Eur J Pharmacol. 2001 May 11;419(2-3):163-74.

2. Matsumoto RR, et al. Eur J Pharmacol. 1995 Jul 14;280(3):301-10.

3. Wu Z, et al. J Biol Chem. 2008 Oct 17;283(42):28198-215.

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