BDA-366 |Cas:1909226-00-1 Buy BDA-366 from ProbeChem, Global Biochemicals Supplier

Chemical Structure : BDA-366

CAS No.: 1909226-00-1

BDA-366 (NSC-639366;NSC639366;BDA366)

Catalog No.: PC-60281Not For Human Use, Lab Use Only.

BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$378	In stock
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Biological Activity

BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM.
BDA-366 (NSC639366) shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.
BDA-366 (NSC639366) induces apoptotic cell death in a Bax-dependent manner, and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction; potently represses lung cancer in vivo.
BDA-366 (NSC639366) induces Bcl2 conformational change in tumor tissues.

Physicochemical Properties

M.Wt	423.5
Formula	C24H29N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione

References

1. Han B, et al. Cancer Cell. 2015 Jun 8;27(6):852-63.

2. Deng J, et al. Oncotarget. 2016 May 10;7(19):27753-63.

3. Vervloessem T, et al. Aging (Albany NY). 2015 Oct;7(10):748-9.

BDA-366 (NSC-639366;NSC639366;BDA366)

Biological Activity

Physicochemical Properties

References

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