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Chemical Structure : BDA-366
CAS No.: 1909226-00-1
Catalog No.: PC-60281Not For Human Use, Lab Use Only.
BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BDA-366 (NSC639366) is a potent, selective Bcl2 BH4 domain antagonist with Ki of 3.3 nM.
BDA-366 (NSC639366) shows no affinity for other Bcl2 family members, including Bcl-XL, Mcl-1, or Bfl-1/A1.
BDA-366 (NSC639366) induces apoptotic cell death in a Bax-dependent manner, and induces calcium (Ca2+) release via inhibition of Bcl2/IP3R interaction; potently represses lung cancer in vivo.
BDA-366 (NSC639366) induces Bcl2 conformational change in tumor tissues.
| M.Wt | 423.5 | |
| Formula | C24H29N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione |
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1. Han B, et al. Cancer Cell. 2015 Jun 8;27(6):852-63.
2. Deng J, et al. Oncotarget. 2016 May 10;7(19):27753-63.
3. Vervloessem T, et al. Aging (Albany NY). 2015 Oct;7(10):748-9.
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