BDM44931 | BFL-1 inhibitor | Probechem Biochemicals

Chemical Structure : BDM44931

BDM44931 (BDM 44931)

Catalog No.: PC-20240Not For Human Use, Lab Use Only.

BDM44931 is a small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 1.3 uM.

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Biological Activity

BDM44931 is a small molecule inhibitor of anti-apoptotic protein BCL2A1/Bfl-1 with IC50 of 1.3 uM.
BDM44931 exerted proapoptotic effect on BP3 and IM9 cell line in propidium iodide/ Annexin V double staining and flow cytometry, as well as delayed the growth of lymphoid tumor in immunocompromised mice.

Physicochemical Properties

M.Wt	378.45
Formula	C21H18N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-ethoxyphenyl)-5-((E)-3-phenylallylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

References

1. Patent WO2016079067A1.

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BDM44931 (BDM 44931)

Biological Activity

Physicochemical Properties

References

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