BDM_76464 (BDM-76464, BDM76464)

Chemical Structure : BDM_76464

Catalog No.: PC-23921Not For Human Use, Lab Use Only.

BDM_76464 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 23 nM, has >25-fold selecive over ERAP1 and ARAP2.

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Biological Activity

BDM_76464 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 23 nM, has >25-fold selecive over ERAP1 and ARAP2. potently decrease production of IL-2 by B3Z hybridoma with IC50 of 2.91 uM.

Physicochemical Properties

M.Wt	423.51
Formula	C24H29N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[2-(5-Benzyloxy-1H-indol-3-yl)ethyl]-2-(hydroxycarbamoyl)-4-methyl-pentanamide

References

1. He B, et al. J Med Chem. 2025 Feb 7. doi: 10.1021/acs.jmedchem.4c01744.

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