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BDP8900

Chemical Structure : BDP8900

CAS No.: 2226507-05-5

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BDP8900 (BDP 8900;BDP-8900)

Catalog No.: PC-63522Not For Human Use, Lab Use Only.

BDP8900 (BDP-8900) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM (MRCKβ), >100-fold selectivity over related ROCK1 or ROCK2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BDP8900 (BDP-8900) is a highly potent and selective Myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with IC50 of 43 nM (MRCKβ), >100-fold selectivity over related ROCK1 or ROCK2。
    BDP8900 shows similar activity against MRCKα and MRCKβ。
    BDP8900 displays consistent antiproliferative effects with greatest activity in hematologic cancer cells.

    Physicochemical Properties

    M.Wt 353.488
    Formula C19H23N5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(4-(1,8-diazaspiro[5.5]undecan-8-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)thiazole

    References

    1. Unbekandt M, et al. Cancer Res. 2018 Apr 15;78(8):2096-2114.

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