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Chemical Structure : BDT001
Catalog No.: PC-63198Not For Human Use, Lab Use Only.
BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM.
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BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM.
BDT001 inhibits FL-induced FLT3 phosphorylation in leukemia-derived RS4-11 cells with IC50 of 18-24 uM.
BDT001 reverses the potentiation by FL with a maximal effect at 1 uM, with no effect on capsaicin-induced TRPV1 activation nor basal Ca2+ in primary cultures of adult DRG neurons.
BDT001 strongly reduces nerve injury-induced sensory hypersensitivity, with no effect on nociception in non-injured animals.
| M.Wt | 394.87 | |
| Formula | C18H19ClN2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Rivat C, et al. Nat Commun. 2018 Mar 12;9(1):1042.
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