Catalog No.: PC-21566Not For Human Use, Lab Use Only.
Silevertinib (BDTX-1535) is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC.
Silevertinib (BDTX-1535) is a 4th generation, irreversible, CNS penetrant, potent, wild type sparing EGFR inhibitor, targets a family of oncogenic EGFR extracellular domain alterations and amplification in GBM, and EGFR resistance mutations in NSCLC.
BDTX-1535 achieves potent anti-tumor activity against EGFR alterations and amplification across models including NSCLC and GBM PDX and intracranial tumors.
