BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants.
BDTX-189 (Tuxobertinib) shows KD value s of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively.
BDTX-189 (Tuxobertinib) inactivates multiple allosteric ERBB mutants in vivo, achieves dose-dependent regression of allosteric HER2 and EGFR tumors.
