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BDW568

Chemical Structure : BDW568

CAS No.: 335401-44-0

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BDW568 (BDW-568)

Catalog No.: PC-22431Not For Human Use, Lab Use Only.

BDW568 is a non-nucleotide agonist of human STING (stimulator of interferon genes) and type-I interferon signaling activator.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BDW568 is a non-nucleotide agonist of human STING (stimulator of interferon genes) and type-I interferon signaling activator.
BDW568 could robustly activate the STING pathway in human primary peripheral blood mononuclear cells (PBMCs) with STINGA230 genotype from healthy individuals.
BDW568 could robustly activate type I interferon signaling in purified human primary macrophages that were transduced with lentivirus expressing STINGA230.

Physicochemical Properties

M.Wt 308.37
Formula C12H12N4O2S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methyl 2-[(8,9-dimethylthieno[3,2-e]-1,2,4-triazolo[4,3-c]pyrimidin-3-yl)thio]acetate

References

1. Zhao J, et al. ACS Cent Sci. 2022 Oct 26;8(10):1424-1434.

2. Tang Z, et al. bioRxiv [Preprint]. 2023 Jul 10:2023.07.02.547363.

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