BE21349 | hCA IX/XII inhibitor | Probechem Biochemicals

Chemical Structure : BE21349

BE21349 (BE-21349)

Catalog No.: PC-27243Not For Human Use, Lab Use Only.

BE21349 is a potent, selective dual inhibitor of carbonic anhydrases hCA IX and XII with Ki of 61.8 nM and 40.5 nM for hCA IX and hCA XII respectively.

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Biological Activity

BE21349 is a potent, selective dual inhibitor of carbonic anhydrases hCA IX and XII with Ki of 61.8 nM and 40.5 nM for hCA IX and hCA XII respectively.
BE21349 shows 33- and 51-fold selectivity for these respective isoforms over hCA I (Ki= 2090 nM).
BE21349 exhibits antiproliferative activity across the NCI-60 panel.

Physicochemical Properties

M.Wt	434.47
Formula	C22H18N4O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-(3-((2-hydroxy-5-methylbenzylidene)amino)-4-oxo-3,4-dihydroquinazolin-2-yl)benzenesulfonamide

References

1. Hazem Essam Okda, et al. J Med Chem. 2026 Jul 9;69(13):16036-16060.

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BE21349 (BE-21349)

Biological Activity

Physicochemical Properties

References

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