Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BETd-246
Catalog No.: PC-60931Not For Human Use, Lab Use Only.
A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, second-generation BET protein degrader that exhibits superior selectivity, potency and antitumor activity; completely and selectively depletes BRD2, BRD3 and BRD4 in representative TNBC cell lines with 30-100 nM for 1 h or with 10-30 nM for 3 h incubation; displays strong growth inhibition and apoptosis induction activity in TNBC cell lines with IC50 <1 uM, induces a rapid and time-dependent downregulation of MCL1 protein; decreases BET proteins in xenograft breast tumors and suppress tumor growth in vivo without causing weight loss.
| M.Wt | 946.035 | |
| Formula | C48H55N11O10 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Bai L, et al. Cancer Res. 2017 May 1;77(9):2476-2487.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
