Catalog No.: PC-63341Not For Human Use, Lab Use Only.
BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM).
BF738735 is a novel, broad-spectrum inhibitor of enterovirus replication (EC50=4-71 nM) that specifically targets host cell factor PI4KIIIβ with IC50 of 5.7 nM, 300-fold less potent for PI4KIIIα (IC50=1.7 uM).
BF738735 blocks viral RNA replication with IC50 of 77 nM in luciferase assays, strongly inhibits CVB3 and EV71 replicon replication at 1-5 uM.
BF738735 reduces the PI4P levels at the Golgi complex through a direct inhibition of PI4KIIIβ activity.
