Catalog No.: PC-23607Not For Human Use, Lab Use Only.
BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL-1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
BFL-1 inhibitor 20 hydrochloride (Bfl-1-IN-6) is a potent, selective, covalent and orally bioavailable BFL-1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
BFL1 inhibitor 20 is inactive in BCL2, BCL-xl, or MCL1.
BFL1 inhibitor 20 exhibits potent activity on caspase activation in the SUDHL1 cell line when combined with AZD5991(EC50=0.35 uM).
BFL1 inhibitor 20d emonstrated a cell death phenotype in SUDHL1 and OCILY10 cell lines and in the in vivo.
