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BFL-1 inhibitor 4E14

Chemical Structure : BFL-1 inhibitor 4E14

CAS No.:

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BFL-1 inhibitor 4E14 (4E14)

Catalog No.: PC-72541Not For Human Use, Lab Use Only.

4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction).
    4E14 targets a unique C55 residue in the BFL-1 groove.
    4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
    4E14 (BFL-1 BH3 inhibitor 4E14) blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.

    Physicochemical Properties

    M.Wt 408.579
    Formula C19H28N4O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-acetamido-N-(2-((2-(dimethylamino)ethyl)disulfanyl)ethyl)-3-(1H-indol-3-yl)propanamide

    References

    1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.

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