Chemical Structure : BFL1 inhibitor 20
Catalog No.: PC-23607Not For Human Use, Lab Use Only.
BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
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BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
BFL1 inhibitor 20 is inactive in BCL2, BCL-xl, or MCL1.
BFL1 inhibitor 20 exhibits potent activity on caspase activation in the SUDHL1 cell line when combined with AZD5991(EC50=0.35 uM).
BFL1 inhibitor 20d emonstrated a cell death phenotype in SUDHL1 and OCILY10 cell lines and in the in vivo
M.Wt | 439.35 | |
Formula | C22H25Cl2FN2O2 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Palisse A, et al. J Med Chem. 2024 Dec 6. doi: 10.1021/acs.jmedchem.4c01995.
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