BFL1 inhibitor 20

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Chemical Structure : BFL1 inhibitor 20

Catalog No.: PC-23607Not For Human Use, Lab Use Only.

BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BFL1 inhibitor 20 is a potent, selective, covalent and orally bioavailable BFL1 inhibitor with IC50 of 19 nM in TR-FRET assays, binds to Cys55 of BFL1.
BFL1 inhibitor 20 is inactive in BCL2, BCL-xl, or MCL1.
BFL1 inhibitor 20 exhibits potent activity on caspase activation in the SUDHL1 cell line when combined with AZD5991(EC50=0.35 uM).
BFL1 inhibitor 20d emonstrated a cell death phenotype in SUDHL1 and OCILY10 cell lines and in the in vivo

Physicochemical Properties

M.Wt	439.35
Formula	C22H25Cl2FN2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(((1R,3R)-3-aminocyclopentyl)oxy)-3-fluorophenyl)-N-((S)-1-(4-chlorophenyl)ethyl)acrylamide hydrochloride

References

1. Palisse A, et al. J Med Chem. 2024 Dec 6. doi: 10.1021/acs.jmedchem.4c01995.

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