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Chemical Structure : BGC20-1531
CAS No.: 1962928-26-2
Catalog No.: PC-36058Not For Human Use, Lab Use Only.
BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $188 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BGC20-1531 (PGN-1531, AP 1531) is a potent, selective prostanoid EP receptor EP4 antagonist, exhibits high affinity at recombinant human EP4 receptors expressed in cell lines (pKB=7.6) and native EP4 receptors in human cerebral and meningeal artery (pKB=7.6-7.8).
BGC20-1531 shows no appreciable affinity at a wide range of other receptors (including other prostanoid receptors), channels, transporters and enzymes (pKi < 5).
BGC20-1531 competitively antagonizes PGE(2)-induced vasodilatation of human middle cerebral (pK(B) 7.8) and meningeal (pK(B) 7.6) arteries in vitro, and PGE(2)-induced increase in canine carotid blood flow in vivo.
| M.Wt | 529.004 | |
| Formula | C26H25ClN2O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride |
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1. Maubach KA, et al. Br J Pharmacol. 2009 Jan;156(2):316-27.
2. Antonova M, et al. J Headache Pain. 2011 Oct;12(5):551-9.
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