BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels.
BGP-15 markedly increases the phosphorylation of HSF1 and expression of HSF1 and HSP72 in adipocytes and muscle cells.
BGP-15 protects against obesity-induced insulin resistance and orally active.
BGP-15 alleviates ventilation-induced diaphragm dysfunction associated with HSP72 induction and PARP-1 inhibition.
