Chemical Structure : BH400
CAS No.:
BH400
(BH 400, BH-400)
Catalog No.: PC-22732Not For Human Use, Lab Use Only.
BH400 is a potent, bifunctional PPARα/STING modulator, agonizes PPARα (EC50=1.2 μM) and inhibits STING (IC50=8.1 μM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BH400 is a potent, bifunctional PPARα/STING modulator, agonizes PPARα (EC50=1.2 μM) and inhibits STING (IC50=8.1 μM).
BH400 (0-10 uM) shows dose-dependent protection against CoCl2-induced reactive oxygen species (ROS) in HMC3 cells (microglial cell line), rescues the expression of PCG1α following the LPS treatment, reduces LPS-induced secretion of interleukin 6 (IL-6).
BH400 shows superior protection of cell viability over selective STING inhibition. BH400 exhibits superior protection against ROS production in microglial cells (HMC3) compared with selective PPARα agonism and an improvement in photoreceptor (661W) cell viability beyond that observed for selective STING inhibition.
BH400 exhibits PPARα agonistic and STING inhibitory dual modulation activity.
Physicochemical Properties
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M.Wt
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337.35
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Formula
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C20H16FNO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(((4'-fluoro-[1,1'-biphenyl]-4-yl)methyl)amino)-2-hydroxybenzoic acid
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References
1. Bo Hu, et al. ACS Medicinal Chemistry Letters, July 22, 2024
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