Catalog No.: PC-49227Not For Human Use, Lab Use Only.
BI-1622 (BI 1622) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 7 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR.
BI-1622 (BI 1622) is a potent, selective, covalent and orally active HER2 inhibitor with IC50 of 7 nM, potently inhibits HER2 exon 20 mutants while sparing WT EGFR.
BI-1622 (5 uM) inhibits the proliferation of HER2-dependent cell lines, dose-dependently decreases pHER2 and pERK levels in NCI-H2170 HER2YVMA and PC-9 HER2YVMA cells.
BI-1622 inhibits tumor growth and inhibits oncogenic signaling in preclinical xenograft models of HER2 exon 20 mutant non-small cell lung cancer.
