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BI-1915

Chemical Structure : BI-1915

CAS No.: 752237-67-5

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BI-1915 (BI 1915)

Catalog No.: PC-38292Not For Human Use, Lab Use Only.

BI-1915 (BI 1915) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 17 nM for in vitro use, no significant inhibition on Cathepsin L/K/B (IC50>10 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI-1915 (BI 1915) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 17 nM for in vitro use, no significant inhibition on Cathepsin L/K/B (IC50>10 uM).
    BI-1915 effectively blocks the specific ovalbumin induced IL-2 secretion in T-cells with an EC50 value of 2.8 nM.
    BI-1915 shows excellent selectivity against related cathepsins with IC50 values of >10 µM (Cat K and Cat B) and >30 µM (Cat L).

    Physicochemical Properties

    M.Wt 407.559
    Formula C21H37N5O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(1-((4-cyano-1-methylpiperidin-4-yl)amino)-5,5-dimethyl-1-oxoheptan-2-yl)morpholine-4-carboxamide

    References

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