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BI-1950

Chemical Structure : BI-1950

CAS No.: 1159724-42-1

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BI-1950 (BI1950)

Catalog No.: PC-35035Not For Human Use, Lab Use Only.

BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI-1950 is a potent, selective LFA-1 antagonist that inhibits the binding of LFA-1 to ICAM-1 with Kd value of 9 nM.
    BI-1950 displays >1,000 fold selectivity against the most closely related b2-integrin Mac-1 and b1-integrin function.
    BI-1950 inhibits the production of IL-2 in human PBMC and whole blood with IC50 value of 3 nM and 120 nM, respectively.
    BI-1950 exhibits an attractive DMPK profile, BI-1950 is a excellent molecule for testing pharmacological hypotheses in vitro and in vivo.

    Physicochemical Properties

    M.Wt 646.504
    Formula C32H26Cl2FN7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-3-(4-cyanobenzyl)-1-(3,5-dichloro-4-fluorophenyl)-3-methyl-2-oxo-N-((S)-1-oxo-1-((1-(pyridin-2-yl)cyclopropyl)amino)propan-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazole-5-carboxamide

    References

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