Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Find Your Distributors

Select Your Country or Region

 $ USD

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Apoptosis-Bcl-2-BI-3802
BI-3802

Chemical Structure : BI-3802

CAS No.: 2166387-65-9

Add to Favorites

BI-3802 (BI3802, BI 3802)

Catalog No.: PC-60949Not For Human Use, Lab Use Only.

BI-3802 (BI3802) is a highly potent and efficacious BCL6 degrader that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

Packing Price Stock Quantity
5 mg $328 In stock
10 mg $528 In stock
25 mg $898 In stock
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI-3802 (BI 3802) is a small molecule B cell lymphoma 6 (BCL6) degrader, binds the Broad complex/Tramtrack/Bric-a-brac (BTB) domain and induces BCL6 degradation.
BI-3802 induced degradation of the full-length BCL6 reporter, while the inhibitor, BI-3812, did not alter stability of the reporter, which can be attenuated by chemical inhibition of the 26S proteasome with MG132 or inhibition of the ubiquitin activating enzyme UBA1 by MLN7243 (TAK-243).
BI-3802 induces cellular BCL6 foci and BCL6 polymerization.
Mutation of Y58 to alanine in BCL6 prevents BI-3802 binding in vitro.
The non-cullin E3 ubiquitin ligase SIAH1 is involved in degradation of polymerized BCL6, BI-3802 increased the interaction between BCL6 and SIAH1 (EC50=64 nM) both in vitro and in cells.

Physicochemical Properties

M.Wt 484.985
Formula C24H29ClN6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((6-((5-chloro-2-((3S,5R)-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)oxy)-N-methylacetamide

References

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.
2. Mikołaj Słabicki, et al. Nature. 2020 Dec;588(7836):164-168.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: