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BI-3812

Chemical Structure : BI-3812

CAS No.: 2166387-64-8

BI-3812 (BI3812;BI 3812)

Catalog No.: PC-60950Not For Human Use, Lab Use Only.

BI-3812 is a highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI-3812 is a highly potent and efficacious BCL6 inhibitor that potently inhibits the interaction of the BTB/POZ domain of BCL6 with several co-repressors in vitro with IC50 of <3 nM.
BI-3812 inhibits the BCL6/Co-repressor complex formation with IC50 of 40 nM in vitro.

Physicochemical Properties

M.Wt 558.036
Formula C26H32ClN7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-(5-chloro-4-((8-methoxy-1-methyl-3-(2-(methylamino)-2-oxoethoxy)-2-oxo-1,2-dihydroquinolin-6-yl)amino)pyrimidin-2-yl)-N,N-dimethylpiperidine-4-carboxamide

References

1. Kerres N, et al. Cell Rep. 2017 Sep 19;20(12):2860-2875.

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