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BI-78D3

Chemical Structure : BI-78D3

CAS No.: 883065-90-5

BI-78D3 (BI 78D3;BI78D3)

Catalog No.: PC-42552Not For Human Use, Lab Use Only.

BI-78D3 is a small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI-78D3 is a small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.
BI-78D3 targets the JNK-JIP interaction site and dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell.
BI-78D3 blocks JNK dependent Con A-induced liver damage, restores insulin sensitivity in mouse models of type 2 diabetes.

Physicochemical Properties

M.Wt 379.37106
Formula C13H9N5O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 31 mg/mL

Chemical Name/SMILES

3H-1,2,4-Triazol-3-one, 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-

References

1. Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13.

2. Strittmatter F, et al. Br J Pharmacol. 2012 Jul;166(6):1926-35.

3. Posthumadeboer J, et al. Oncotarget. 2012 Oct;3(10):1169-81.

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