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Chemical Structure : BI-78D3
CAS No.: 883065-90-5
Catalog No.: PC-42552Not For Human Use, Lab Use Only.
BI-78D3 is a small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BI-78D3 is a small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM.
BI-78D3 targets the JNK-JIP interaction site and dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell.
BI-78D3 blocks JNK dependent Con A-induced liver damage, restores insulin sensitivity in mouse models of type 2 diabetes.
| M.Wt | 379.37106 | |
| Formula | C13H9N5O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
3H-1,2,4-Triazol-3-one, 4-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]- |
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1. Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13.
2. Strittmatter F, et al. Br J Pharmacol. 2012 Jul;166(6):1926-35.
3. Posthumadeboer J, et al. Oncotarget. 2012 Oct;3(10):1169-81.
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