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BI-853520

Chemical Structure : BI-853520

CAS No.: 1227948-82-4

BI-853520 (Ifebemtinib, BI 853520, IN10018)

Catalog No.: PC-60275Not For Human Use, Lab Use Only.

Ifebemtinib (BI 853520, IN10018) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.

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Biological Activity

Ifebemtinib (BI 853520, IN10018) is potent, highly selective and orally active inhibitor of PTK2/FAK with IC50 of 1 nM in cell-free assays.
BI 853520 inhibits only 4 enzymes at 10 uM in a panel of 264 tyrosine and serine/threonine kinases.
BI 853520 inhibits the colony formation of PC-3 cells with EC50 of 3 nM.
BI 853520 suppresses PTK2 autophosphorylation in tissue samples from both human tumor xenografts and mouse skin.
BI 853520 demonstrates anti-tumor activity in vivo.

Physicochemical Properties

M.Wt 588.56
Formula C28H28F4N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-fluoro-5-methoxy-4-((4-((2-methyl-3-oxoisoindolin-4-yl)oxy)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-N-(1-methylpiperidin-4-yl)benzamide

References

1. Roy-Luzarraga M, et al. Clin Cancer Res. 2016 Aug 1;22(15):3718-24.

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