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BI-8668

Chemical Structure : BI-8668

CAS No.: 2084059-97-0

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BI-8668 (BI 8668)

Catalog No.: PC-38297Not For Human Use, Lab Use Only.

BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI-8668 (BI 8668) is a highly potent and selective epithelial sodium channel (ENaC) inhibitor, inhibits Na+ current with IC50 of 17 nM (Ussing chamber assay).
    BI-8668 inhibits ENaC-mediated water permeability through cell monolayers of the cell line M-1 (M-1 cells: mouse kidney tubules cells) with 81% inhibition at 3 uM.

    Physicochemical Properties

    M.Wt 523.463
    Formula C23H32Cl2N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-((3-amino-6-chloropyrazine-2-carboxamido)methyl)-6-((2-(dimethylamino)ethyl)(methyl)carbamoyl)-1,3-diethyl-1H-benzo[d]imidazol-3-ium chloride

    References

    1. Betzemeier B, et al. Eur J Med Chem. 2023 Dec 18;265:116038.

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