BI-9508 | GPR88 agonist | Probechem Biochemicals

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Chemical Structure : BI-9508

BI-9508 (BI 9508)

Catalog No.: PC-22616Not For Human Use, Lab Use Only.

BI-9508 is a potent, selective and brain penetrant GPR88 agonist with EC50 of 47 nM in hGPR88 Gi1 BRET assay, Emax of 110%.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BI-9508 is a potent, selective and brain penetrant GPR88 agonist with EC50 of 47 nM in hGPR88 Gi1 BRET assay, Emax of 110%.
BI-9508 has EC50 of 94 nM for mGPR88.
BI-9508 shows acceptable selectivity in the CEREP SafetyScreen44
BI-9508 show improved pharmacokinetic properties and dosing for future in vivo studies in rodents.

Physicochemical Properties

M.Wt	521.57
Formula	C28H29F2N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2R)-N-(2-(Difluoromethoxy)ethyl)-N-(4-(4-isopropoxyphenyl)-1-methyl-1H-indazol-7-yl)-2-(pyrimidin-4-yl)cyclopropane-1-carboxamide

References

1. Fer M, et al. J Med Chem. 2024 Jul 1. doi: 10.1021/acs.jmedchem.4c00665.

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BI-9508 (BI 9508)

Biological Activity

Physicochemical Properties

References

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