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Chemical Structure : BI-9508
Catalog No.: PC-22616Not For Human Use, Lab Use Only.
BI-9508 is a potent, selective and brain penetrant GPR88 agonist with EC50 of 47 nM in hGPR88 Gi1 BRET assay, Emax of 110%.
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BI-9508 is a potent, selective and brain penetrant GPR88 agonist with EC50 of 47 nM in hGPR88 Gi1 BRET assay, Emax of 110%.
BI-9508 has EC50 of 94 nM for mGPR88.
BI-9508 shows acceptable selectivity in the CEREP SafetyScreen44
BI-9508 show improved pharmacokinetic properties and dosing for future in vivo studies in rodents.
| M.Wt | 521.57 | |
| Formula | C28H29F2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fer M, et al. J Med Chem. 2024 Jul 1. doi: 10.1021/acs.jmedchem.4c00665.
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