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BI-99179

Chemical Structure : BI-99179

CAS No.: 1291779-76-4

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BI-99179 (BI99179)

Catalog No.: PC-35031Not For Human Use, Lab Use Only.

BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS) with IC50 of 79 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI-99179 is a potent and selective inhibitor of type I fatty acid synthase (FAS, FASN) with IC50 of 79 nM.
    BI-99179 demonstrates potent cellular activity (inhibition of 14C-acetate incorporation) with IC50 of 0.6 uM in the mouse N-42 cellular assays, shows no significant LDH release in the cytotoxicity assay at >30 uM.
    BI-99179 is a tool compound suitable for the in vivo validation of FAS as a therapeutic target.

    Physicochemical Properties

    M.Wt 391.471
    Formula C23H25N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,3S)-N-(4-(benzo[d]oxazol-2-yl)phenyl)-N-methyl-3-propionamidocyclopentane-1-carboxamide

    References

    1. Kley JT, et al. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5924-7.

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