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Chemical Structure : BI1071
Catalog No.: PC-36149Not For Human Use, Lab Use Only.
BI1071 (BI-1071, DIM-C-pPhCF3+MeSO3-) is a novel Nur77 modulator and modulator of the Nur77-Bcl-2 apoptotic pathway, binds Nur77 (Kd=0.17 uM) to induce its mitochondrial targeting and apoptosis.
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BI1071 (BI-1071, DIM-C-pPhCF3+MeSO3-) is a novel Nur77 modulator and modulator of the Nur77-Bcl-2 apoptotic pathway, binds Nur77 (Kd=0.17 uM) to induce its mitochondrial targeting and apoptosis.
BI1071 promotes Nur77 mitochondrial targeting and interaction with Bcl-2, and effectively induces apoptosis of cancer cells in a Nur77- and Bcl-2-dependent manner.
BI1071 inhibited the growth of HCT116 colon cancer cell with IC50 of 0.06 uM, 25-fold more active than DIM-C-pPhCF3.
BI1071 BI1071 potently inhibits the growth of tumor cells in animals through its induction of apoptosis in animal models.
| M.Wt | 484.493 | |
| Formula | C25H19F3N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen X, et al. Mol Cancer Ther. 2019 Mar 29. pii: molcanther.0918.2018.
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