Chemical Structure : BI1071
CAS No.:
BI1071
(BI 1071;BI-1071;DIM-C-pPhCF3+MeSO3-)
Catalog No.: PC-36149Not For Human Use, Lab Use Only.
BI1071 (BI-1071, DIM-C-pPhCF3+MeSO3-) is a novel Nur77 modulator and modulator of the Nur77-Bcl-2 apoptotic pathway, binds Nur77 (Kd=0.17 uM) to induce its mitochondrial targeting and apoptosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BI1071 (BI-1071, DIM-C-pPhCF3+MeSO3-) is a novel Nur77 modulator and modulator of the Nur77-Bcl-2 apoptotic pathway, binds Nur77 (Kd=0.17 uM) to induce its mitochondrial targeting and apoptosis.
BI1071 promotes Nur77 mitochondrial targeting and interaction with Bcl-2, and effectively induces apoptosis of cancer cells in a Nur77- and Bcl-2-dependent manner.
BI1071 inhibited the growth of HCT116 colon cancer cell with IC50 of 0.06 uM, 25-fold more active than DIM-C-pPhCF3.
BI1071 BI1071 potently inhibits the growth of tumor cells in animals through its induction of apoptosis in animal models.
Physicochemical Properties
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M.Wt
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484.493
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Formula
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C25H19F3N2O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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di(1H-indol-3-yl)(4-(trifluoromethyl)phenyl)methylium methanesulfonate
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References
1. Chen X, et al. Mol Cancer Ther. 2019 Mar 29. pii: molcanther.0918.2018.
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