Catalog No.: PC-60448Not For Human Use, Lab Use Only.
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
BI 135585 (BI-135585, BI135585) is a potent, selective, orally active 11β-HSD1 inhibitor with IC50 of 4.3 nM and 53 nM in human adipocytes and primary human adipose tissue, respectively.
BI 135585 exhibits >1,000-fold selectivity over other hydroxysteroid dehydrogenases.
BI 135585 inhibits 11β HSD1 activity in adipose tissue, displays desirable pharmacodynamic properties in vivo.
