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BI 186908

Chemical Structure : BI 186908

CAS No.: 1453500-36-1

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BI 186908 (BI186908)

Catalog No.: PC-61512Not For Human Use, Lab Use Only.

BI 186908 is a potent and selective MCH1 receptor (MCHR1) antagonist with IC50 of 22 nM, Ki of 14 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI 186908 is a potent and selective MCH1 receptor (MCHR1) antagonist with IC50 of 22 nM, Ki of 14 nM.
    BI 186908 significantly reduces body weight comparable to sibutramine in a 4 week diet-induced obesity model in rats, possesses favorable DMPK and CMC properties.

    Physicochemical Properties

    M.Wt 422.485
    Formula C23H26N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(4-((dimethylamino)methyl)-2-methylphenyl)-2-oxoethyl)-5-((5-methoxypyridin-2-yl)methoxy)pyridazin-3(2H)-one

    References

    1. Oost T, et al. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3275-80.

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