BI 409306 |CAS:1189767-28-9 Probechem Biochemicals

Chemical Structure : BI 409306

CAS No.: 1189767-28-9

BI 409306 (BI-409306, SUB 166499)

Catalog No.: PC-60208Not For Human Use, Lab Use Only.

BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with IC50 of 65 nM and 168 nM, respectively.

Packing	Price	Stock
5 mg	$228	In stock
10 mg	$378	In stock
25 mg	$598	In stock
100 mg	$1280	In stock
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Biological Activity

BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with IC50 of 65 nM and 168 nM, respectively.

BI 409306 increased cGMP levels in rat prefrontal cortex and cerebrospinal fluid and attenuated a reduction in mouse striatum cGMP induced by the NMDA-receptor antagonist MK-801.

BI 409306 enhanced LTP induced by both weak and strong tetanic stimulation in ex vivo rat brain slices.

BI 409306 reversed MK-801-induced working memory deficits in a T-maze spontaneous-alternation task and improved long-term memory in an object recognition task in mice.

BI 409306 increased brain cGMP levels, promoted long-term potentiation, and improved episodic and working memory performance in rodents.

Physicochemical Properties

M.Wt	311.345
Formula	C16H17N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

1. Moschetti V, et al. Br J Clin Pharmacol. 2016 Nov;82(5):1315-1324.

2. Brown D, et al. Neurol Ther. 2017 Nov 24. doi: 10.1007/s40120-017-0085-5.
3. Rosenbrock H, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):633-641.

BI 409306 (BI-409306, SUB 166499)

Biological Activity

Physicochemical Properties

References

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