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BI 671800

Chemical Structure : BI 671800

CAS No.: 1093108-50-9

BI 671800 (BI-671800)

Catalog No.: PC-61563Not For Human Use, Lab Use Only.

BI 671800 is a potent, oral prostaglandin D2 receptor (DP2/CRTH2) antagonist with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BI 671800 is a potent, oral prostaglandin D2 receptor (DP2/CRTH2) antagonist with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.
BI 671800 effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals

Physicochemical Properties

M.Wt 501.5
Formula C25H26F3N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4,6-bis(dimethylamino)-2-((4-((4-(trifluoromethyl)benzoyl)amino)phenyl)methyl)-5-pyrimidineacetic acid

References

1. Krug N, et al. J Allergy Clin Immunol. 2014 Feb;133(2):414-9.

2. Hall IP, et al. Pulm Pharmacol Ther. 2015 Jun;32:37-44.

3. Miller D, et al. Allergy Asthma Proc. 2017 Mar 1;38(2):157-164.

4. Kupczyk M, et al. Drugs. 2017 Aug;77(12):1281-1294.

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