Chemical Structure : BI 671800
CAS No.: 1093108-50-9
Catalog No.: PC-61563Not For Human Use, Lab Use Only.
BI 671800 is a potent, oral prostaglandin D2 receptor (DP2/CRTH2) antagonist with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.
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10 mg | $248 | In stock | |
25 mg | $398 | In stock | |
50 mg | $588 | In stock | |
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BI 671800 is a potent, oral prostaglandin D2 receptor (DP2/CRTH2) antagonist with IC50 of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively.
BI 671800 effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals
M.Wt | 501.5 | |
Formula | C25H26F3N5O3 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
4,6-bis(dimethylamino)-2-((4-((4-(trifluoromethyl)benzoyl)amino)phenyl)methyl)-5-pyrimidineacetic acid |
1. Krug N, et al. J Allergy Clin Immunol. 2014 Feb;133(2):414-9.
2. Hall IP, et al. Pulm Pharmacol Ther. 2015 Jun;32:37-44.
3. Miller D, et al. Allergy Asthma Proc. 2017 Mar 1;38(2):157-164.
4. Kupczyk M, et al. Drugs. 2017 Aug;77(12):1281-1294.
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