Catalog No.: PC-63515Not For Human Use, Lab Use Only.
BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM).
BI8626 (BI-8626) is a specific, small molecule inhibitor of the HUWE1 ubiquitin ligase with IC50 of 0.9 uM, does not inhibit the activity of other HECT-domain ubiquitin ligases (HECW2, NEDD4,UBA1 and UbcH5b, IC50>50 uM).
BI8626 suppresses colony formation of Ls174T cells with IC50 of 0.7 uM.
BI8626 inhibits MYC-dependent transactivation in colorectal cancer cells, but not in stem and normal colon epithelial cells.
BI8626 stabilizes MYC-associated protein MIZ1.
