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Chemical Structure : BI 885578
Catalog No.: PC-60348Not For Human Use, Lab Use Only.
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
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BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
BI 885578 inhibits IGF1R/InsR cellular autophosphorylation with IC50 of 5 nM/5 nM respectively.
BI 885578 significantly reduces the growth of xenografted human GEO and CL-14 colon carcinoma tumors, displays an acceptable tolerability profile in mice.
| M.Wt | 527.677 | |
| Formula | C29H37N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sanderson MP, et al. Mol Cancer Ther. 2015 Dec;14(12):2762-72.
2. Sanderson MP, et al. Mol Cancer Ther. 2017 Jul 20. pii: molcanther.0336.2017.
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