Catalog No.: PC-60348Not For Human Use, Lab Use Only.
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
BI 885578 (BI-885578, BI885578) is a potent,selective, ATP-competitive IGF1R/InsR tyrosine kinase inhibitor with Kd of 9 nM/12 nM, IC50 of 1 nM/1 nM, respectively.
BI 885578 inhibits IGF1R/InsR cellular autophosphorylation with IC50 of 5 nM/5 nM respectively.
BI 885578 significantly reduces the growth of xenografted human GEO and CL-14 colon carcinoma tumors, displays an acceptable tolerability profile in mice.
