Chemical Structure : BI 891065
CAS No.:
1875100-07-4
BI 891065
(BI-891065)
Catalog No.: PC-25462Not For Human Use, Lab Use Only.
BI 891065 is a potent, monovalent, oral SMAC mimetic antagonist of cIAP1 with IC50 of <1 nM, 15 nM and >200 nM for cIAP1, cIAP2, and XIAP respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BI 891065 is a potent, monovalent, oral SMAC mimetic antagonist of cIAP1 with IC50 of <1 nM, 15 nM and >200 nM for cIAP1, cIAP2, and XIAP respectively.
BI 891065 exhibits higher affinity toward cIAP1 compared to cIAP2 and more than 200-fold lower affinity toward XIAP.
BI 891065 and BET inhibitor BI 894999 combination induces multiple forms of cell death in vitro.
BI 891065 and BET inhibitor BI 894999 combination is effective in colorectal patient-derived organoid models and in pancreatic and colorectal in vivo xenografts, impairs tumor growth of a pancreatic syngeneic model.
Physicochemical Properties
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M.Wt
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581.68
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Formula
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C35H31N7O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-N-(5-(2-(2-methoxypyridin-3-yl)-7-methylimidazo[1,2-a]pyridin-3-yl)-6-((1-methylisoquinolin-6-yl)ethynyl)pyridin-2-yl)-2-(methylamino)propanamide
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References
1. Slavic Obradovic K, et al. Cell Rep Med. 2025 Aug 21:102313.
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