Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BIBO3304
CAS No.: 191868-14-1
Catalog No.: PC-62525Not For Human Use, Lab Use Only.
BIBO3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $178 | In stock | |
| 10 mg | $288 | In stock | |
| 25 mg | $498 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BIBO3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.
BIBO3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor, human and rat Y5 receptor (IC50>1,000 nM).
BIBO3304 inhibits the feeding response induced by 1 mg NPY in mice, also completely abolishes PYY-induced inhibition of insulin release in vivo.
| M.Wt | 643.668 | |
| Formula | C31H36F3N7O5 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate |
|
1. Wieland HA, et al. Br J Pharmacol. 1998 Oct;125(3):549-55.
2. Capurro D, et al. Eur J Pharmacol. 1999 Jul 9;376(3):251-5.
3. Loh K, et al. Nat Commun. 2017 Sep 8;8(1):490.
4. Kask A, et al. Neuropharmacology. 2000 Apr 27;39(7):1292-302.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
