You are here:Home-Chemical Inhibitors & Agonists-GPCR-Neuropeptide Y Receptor-BIBO3304
BIBO3304

Chemical Structure : BIBO3304

CAS No.: 191868-14-1

BIBO3304 (BIBO 3304, BIBO-3304)

Catalog No.: PC-62525Not For Human Use, Lab Use Only.

BIBO3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.

Packing Price Stock Quantity
5 mg $178 In stock
10 mg $288 In stock
25 mg $498 In stock
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BIBO3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor (NPY1R) antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.
BIBO3304 shows low affinity for the human Y2 receptor, human and rat Y4 receptor, human and rat Y5 receptor (IC50>1,000 nM).
BIBO3304 inhibits the feeding response induced by 1 mg NPY in mice, also completely abolishes PYY-induced inhibition of insulin release in vivo.

Physicochemical Properties

M.Wt 643.668
Formula C31H36F3N7O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-(2,2-diphenylacetamido)-5-guanidino-N-(4-(ureidomethyl)benzyl)pentanamide 2,2,2-trifluoroacetate

References

1. Wieland HA, et al. Br J Pharmacol. 1998 Oct;125(3):549-55.

2. Capurro D, et al. Eur J Pharmacol. 1999 Jul 9;376(3):251-5.

3. Loh K, et al. Nat Commun. 2017 Sep 8;8(1):490.

4. Kask A, et al. Neuropharmacology. 2000 Apr 27;39(7):1292-302.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: