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BIBX 1382

Chemical Structure : BIBX 1382

CAS No.: 196612-93-8

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BIBX 1382 (Falnidamol;BIBX-1382;BIBX1382)

Catalog No.: PC-42522Not For Human Use, Lab Use Only.

BIBX 1382 (Falnidamol) is a selective EGFR inhibitor with IC50 of 3 nM.

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5 mg $88 In stock
10 mg $128 In stock
25 mg $218 In stock
50 mg $358 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BIBX 1382 (Falnidamol) is a selective EGFR inhibitor with IC50 of 3 nM.
BIBX 1382 shows weak activity against HER2 (IC50=3.4 uM) and no inhibition on IGF1R, HGFR, Src, and VEGFR2 (IC50>10 uM).
BIBX 1382 inhibits EGF-induced phosphorylation of EGFR in a dose-dependent manner in A431 cells; orally active in xenografts mice.

Physicochemical Properties

M.Wt 387.8418
Formula C18H19ClFN7
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 41 mg/mL
Chemical Name/SMILES

Pyrimido[5,4-d]pyrimidine-2,8-diamine, N8-(3-chloro-4-fluorophenyl)-N2-(1-methyl-4-piperidinyl)-

References

1. Solca FF, et al. J Pharmacol Exp Ther. 2004 Nov;311(2):502-9.

2. Hutzler JM, et al. Drug Metab Dispos. 2014 Oct;42(10):1751-60.

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