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BI Compound D

Chemical Structure : BI Compound D

CAS No.: 851658-10-1

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BI Compound D (RSV L-protein inhibitor)

Catalog No.: PC-60361Not For Human Use, Lab Use Only.

BI Compound D is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 89 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BI Compound D is a potent non-nucleoside RSV L-protein polymerase inhibitor with IC50 of 89 nM.
    BI Compound D shows anti-RSV activity with IC50 of 57.6 nM and 47.8 nM for RSV A2 and RSV B-EST, respectively.
    BI Compound D shows weak cytotoxicity (CC50=600 nM).

    Physicochemical Properties

    M.Wt 600.68
    Formula C32H36N6O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-Amino-8-(3-((3,4-dimethoxyphenethyl)amino)propyl)-6,6-dimethyl-2-(4-methyl-3-nitrophenyl)-1H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione

    References

    1. Liuzzi M, et al. J Virol. 2005 Oct;79(20):13105-15.

    2. Mason SW, et al. Nucleic Acids Res. 2004 Sep 8;32(16):4758-67.

    3. Coates M, et al. Antimicrob Agents Chemother. 2017 Jun 26. pii: AAC.00737-17.

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