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BIIL260

Chemical Structure : BIIL260

CAS No.: 204974-93-6

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BIIL260 (BIIL 260, BIIL-260)

Catalog No.: PC-63301Not For Human Use, Lab Use Only.

BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BIIL260 is the active metabolite of BIIL284, shows high affinity to LTB4 receptor on isolated human neutrophil cell membranes with Ki of 1.7 nM.
    BIIL260 potently inhibits LTB(4)-induced intracellular Ca(2+) release in human neutrophils with IC50 of 0.82 nM, interacts with the LTB(4) receptor in a saturable, reversible, and competitive manner.

    Physicochemical Properties

    M.Wt 466.581
    Formula C30H30N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-[[3-[[4-[2-(4-hydroxyphenyl)propan-2-yl]phenoxy]methyl]phenyl]methoxy]benzenecarboximidamide

    References

    1. Hori T, et al. Nat Chem Biol. 2018 Mar;14(3):262-269.

    2. Birke FW, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66.

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