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BILH-434

Chemical Structure : BILH-434

CAS No.: 760169-28-6

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BILH-434 (BILH434)

Catalog No.: PC-62478Not For Human Use, Lab Use Only.

BILH-434 is a potent HPV11 E1/E2/DNA complex inhibitor that binds to the transactivation domain (TAD) of E2 protein with a Kd of 40 nM, has an IC50 of 180 nM in the E1-E2-ori complex formation assay..

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BILH-434 is a potent HPV11 E1/E2/DNA complex inhibitor that binds to the transactivation domain (TAD) of E2 protein with a Kd of 40 nM, has an IC50 of 180 nM in the E1-E2-ori complex formation assay.

    Physicochemical Properties

    M.Wt 608.446
    Formula C29H19Cl2N3O6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2R,3'R,4'S,5'R)-5'-(3,4-dichlorophenyl)-5-methyl-1,3-dioxo-4'-[[4-(thiadiazol-4-yl)phenyl]carbamoyl]spiro[indene-2,2'-oxolane]-3'-carboxylic acid

    References

    1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14.

    2. Wang Y, et al. J Biol Chem. 2004 Feb 20;279(8):6976-85.

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