BIO-7488 | IRAK4 inhibitor | Probechem Biochemicals

Chemical Structure : BIO-7488

BIO-7488 (BIO7488, BIO 7488)

Catalog No.: PC-21921Not For Human Use, Lab Use Only.

BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP).

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Biological Activity

BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP).
BIO-7488 potently inhibits R848 stimulus of 1L-1β production with IC50 of 200 nM in human whole blood assay.
BIO-7488 has limited MDR1 or BCRP efflux liability, supporting the favorable measured rat Kpu,u of 0.3 in rats.
BIO-7488 (10, 30, or 100 mg/kg) demonstrated robust and dose-dependent suppression of multiple cytokines, including IL-1β, TNFα, and IL-6 in LPS challenge rat model.

Physicochemical Properties

M.Wt	447.50
Formula	C23H25N7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-Isopropoxy-2-(1-methyl-2-oxabicyclo[2.1.1]hexan-4-yl)- N-(6-methylpyrazolo[1,5- a]pyrimidin-3-yl)imidazo[1,2- a]pyrimidine-6-carboxamide

References

1. Ryan Evans, et al. J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02226.

BIO-7488 (BIO7488, BIO 7488)

Biological Activity

Physicochemical Properties

References

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