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BIO-7662

Chemical Structure : BIO-7662

CAS No.: 327613-10-5

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BIO-7662 (BIO 7662;BIO7662)

Catalog No.: PC-70014Not For Human Use, Lab Use Only.

BIO-7662 (BIO7662) is a potent, highly selective α4β1 integrin antagonist with Kd of <10 pM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BIO-7662 (BIO7662) is a potent, highly selective α4β1 integrin antagonist with Kd of <10 pM.
    The rate of BIO7662 binding is dependent on the metal ion concentration; directly competes with VCAM-1, CS-1, and BIO1211 for binding to the integrin.

    Physicochemical Properties

    M.Wt 748.896
    Formula C38H48N6O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-4-((S)-4-methyl-2-(N-methyl-2-(4-(3-(o-tolyl)ureido)phenyl)acetamido)pentanamido)-2-((S)-1-(phenylsulfonyl)pyrrolidine-2-carboxamido)butanoic acid

    References

    1. Chen LL, et al. J Biol Chem. 2001 Sep 28;276(39):36520-9.

    2. Egger LA, et al. J Pharmacol Exp Ther. 2003 Sep;306(3):903-13.

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