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Chemical Structure : BIO5192
CAS No.: 327613-57-0
Catalog No.: PC-61300Not For Human Use, Lab Use Only.
BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
BIO5192 displays selectively over a range of other integrins (IC50 are 138, 1053, > 500 and > 10,000 nM for α9β1, α2β1, α4β7 and αIIbβ3, respectively).
BIO5192 mobilizes hematopoietic stem and progenitor cells (HSPCs) alone or combined with plerixafor (AMD3100).
| M.Wt | 817.78 | |
| Formula | C38H46Cl2N6O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid |
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1. Leone DR, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1150-62.
2. Theien BE, et al. Blood. 2003 Dec 15;102(13):4464-71.
3. Ramirez P, et al. Blood. 2009 Aug 13;114(7):1340-3.
4. Bao F, et al. Exp Neurol. 2008 Dec;214(2):160-7.
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