Chemical Structure : BIO5192
CAS No.:
327613-57-0
BIO5192
(BIO-5192, BIO 5192)
Catalog No. : PC-61300Not For Human Use, Lab Use Only.
BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
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Purity & Documentation Purity:
>98% (HPLC) Select Batch: PC-6130001
Biological Activity
BIO5192 (BIO-5192) is a potent, highly selective inhibitor of integrin α4β1 (VLA-4) with Kd of <10 pM, IC50 of 1.8 nM.
Physicochemical Properties
M.Wt
817.78
Formula
C38H46Cl2N6O8S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid
References
1. Leone DR, et al. J Pharmacol Exp Ther. 2003 Jun;305(3):1150-62.
2. Theien BE, et al. Blood. 2003 Dec 15;102(13):4464-71.
3. Ramirez P, et al. Blood. 2009 Aug 13;114(7):1340-3.
4. Bao F, et al. Exp Neurol. 2008 Dec;214(2):160-7.
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