Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BIRT-377
CAS No.: 213211-10-0
Catalog No.: PC-73252Not For Human Use, Lab Use Only.
BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM.
BIRT-377 (BIRT377) is a binds to the I-domain of LFA-1.
BIRT 377 reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1.
BIRT-377 (BIRT377) is a inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro.
BIRT-377 (BIRT377) attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo.
| M.Wt | 442.13 | |
| Formula | C18H15BrCl2N2O2 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione |
|
1. Chowdari NS, et al. Org Lett. 2005 Mar 3;7(5):867-70.
2. Larson RS, et al. Biochemistry. 2005 Mar 22;44(11):4322-31.
3. Sanchez JJ, et al. Acta Neuropathol Commun. 2019 Apr 8;7(1):54.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
