BIX02694 | TGR5 agonist | Probechem Biochemicals

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Chemical Structure : BIX02694

BIX02694 (BIX 02694)

Catalog No.: PC-20447Not For Human Use, Lab Use Only.

BIX02694 (BIX 02694) is a highly potent, in vivo-active TGR5 (GPBAR1) agonist with EC50 of 9 nM in AlphaScreen cAMP assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BIX02694 (BIX 02694) is a highly potent, in vivo-active TGR5 (GPBAR1) agonist with EC50 of 9 nM in AlphaScreen cAMP assays.
BIX02694 cross reacts with mouse GPBAR1 and can impact monocyte response to LPS.
BIX02694 reduces monocyte activation in vitro and proinflammatory cytokine production in vivo reduces EAE disease severity.

Physicochemical Properties

M.Wt	491.03
Formula	C28H31ClN4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(9-(1-(4-chlorophenyl)-4-methyl-1H-imidazole-5-carbonyl)-9-azabicyclo[3.3.1]nonan-3-yl)-N,N-dimethylbenzamide

References

1. Nuruddeen D Lewis, et al. PLoS One. 2014 Jun 26;9(6):e100883.

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BIX02694 (BIX 02694)

Biological Activity

Physicochemical Properties

References

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