Chemical Structure : BK channel modulator BC5
CAS No.:
BK channel modulator BC5
(BC5)
Catalog No.: PC-20753Not For Human Use, Lab Use Only.
BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism.
BC5 shifted the voltage-dependent activation (GV relation) of BK channels to more negative voltages (EC50=2.5 uM).
BC5 also inhibited the outward BK currents at positive voltages in the cytosolic side of the membrane patch.
BC5 perturbs Ca2+-dependent activation, interactions with the allosteric pathway for coupling Ca2+ binding to pore opening.
Physicochemical Properties
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M.Wt
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328.42
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Formula
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C18H24N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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NC(NCCCC(N)C(CC1=CC(OC)=C2C=CC=CC2=C1)=O)=N
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References
1. Guohui Zhang, et al. Nat Commun. 2022 Nov 9;13(1):6784.
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