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Chemical Structure : BK channel modulator BC5
Catalog No.: PC-20753Not For Human Use, Lab Use Only.
BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism.
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BK channel modulator BC5 is an allosteric modulator of BK type Ca2+-activated K+ channels, interacts with the CTD-VSD interface and specifically modulates the Ca2+ dependent activation mechanism.
BC5 shifted the voltage-dependent activation (GV relation) of BK channels to more negative voltages (EC50=2.5 uM).
BC5 also inhibited the outward BK currents at positive voltages in the cytosolic side of the membrane patch.
BC5 perturbs Ca2+-dependent activation, interactions with the allosteric pathway for coupling Ca2+ binding to pore opening.
| M.Wt | 328.42 | |
| Formula | C18H24N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Guohui Zhang, et al. Nat Commun. 2022 Nov 9;13(1):6784.
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