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Chemical Structure : BL-1249
CAS No.: 18200-13-0
Catalog No.: PC-60338Not For Human Use, Lab Use Only.
BL-1249 (BL1249) is a potent K2P2.1 (TREK-1) channel activator, enhance the activity of TREK1 currents and produces relaxation of 30 mM KCl-induced contractions in rat bladder strips with EC50 of 1.12 uM.
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|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $238 | In stock | |
| 25 mg | $398 | In stock | |
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| 100 mg | Get quote |
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BL-1249 (BL1249) is a potent K2P2.1 (TREK-1) channel activator, enhance the activity of TREK1 currents and produces relaxation of 30 mM KCl-induced contractions in rat bladder strips with EC50 of 1.12 uM.
BL-1249 decreases the number of isovolumic contractions, without significantly affecting blood pressure, in anesthetized rat models.
BL-1249 exhibits bladder versus vascular selectivity both in vitro and in vivo.
| M.Wt | 291.35 | |
| Formula | C17H17N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,6,7,8-Tetrahydro-N-[2-(2H-tetrazol-5-yl)phenyl]-1-naphthalenamine |
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1. Tertyshnikova S, et al. J Pharmacol Exp Ther. 2005 Apr;313(1):250-9.
2. Veale EL, et al. Mol Pharmacol. 2014 May;85(5):671-81.
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