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BLT-1

Chemical Structure : BLT-1

CAS No.: 321673-30-7

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BLT-1 (BLT1)

Catalog No.: PC-62034Not For Human Use, Lab Use Only.

BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BLT-1 is an irreversible Scavenger receptor class B member I (SR-BI) inhibitor that blocks SR-BI-mediated selective lipid uptake and bidirectional cholesterol flux with an IC50 of 50 nM; significantly inhibits baicalin-induced cholesterol efflux in THP-1 macrophages.

Physicochemical Properties

M.Wt 241.397
Formula C12H23N3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Hexyl-1-cyclopentanone thiosemicarbazone

References

1. Yu M, et al. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12243-8.

2. Nieland TJ, et al. J Lipid Res. 2007 Aug;48(8):1832-45. Epub 2007 May 28.

3. Yu R, et al. Exp Ther Med. 2016 Dec;12(6):4113-4120.

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