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Chemical Structure : BM-1197
Catalog No.: PC-49799Not For Human Use, Lab Use Only.
BM-1197 (BM1197) is a potent and efficacious dual inhibitor of Bcl-2 and Bcl-xL with Ki of < 1 nM, >1,000-fold selectivity over Mcl-1.
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BM-1197 (BM1197) is a potent and efficacious dual inhibitor of Bcl-2 and Bcl-xL with Ki of < 1 nM, >1,000-fold selectivity over Mcl-1.
BM-1197 induces mechanism-based apoptosis in Mcl1-deficient mouse embryonic fibroblast (MEF) cells.
BM-1197 disrupts the association between BCL-XL and PUMA, induces BAX translocation and cytochrome c release and BAX/BAK-dependent apoptosis in MEF/MCL1 −/− cells.
BM-1197 exerts potent growth-inhibitory activity against small cell lung cancer (SCLC) cells in vitro (H146, IC50=3 nM).
BM-1197 IV daily at 10 mg/kg (5 days per week for 2 weeks) exhibited antitumor efficacy in SCID mice bearing H146 or H1963 cells.
| M.Wt | 1131.77 | |
| Formula | C53H59ClF4N6O7S4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Longchuan Bai, et al. PLoS One. 2014 Jun 5;9(6):e99404.
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