Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BM-1197
Catalog No.: PC-61990Not For Human Use, Lab Use Only.
BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo.
| M.Wt | 1131.774 | |
| Formula | C53H59ClF4N6O7S4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Bai L, et al. PLoS One. 2014 Jun 5;9(6):e99404.
2. Ye L, et al. Tumour Biol. 2015 May;36(5):3447-55.
3. Acasigua GA, et al. Oral Oncol. 2015 Sep;51(9):839-47.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
